His responsibilities include managing the High Throughput Medicinal Chemistry department of the Paris research centre (Vitry and Romainville).
He started his career with Rhone Poulenc Health Care in 1979 and was appointed to distinguished positions in particular as head of Chemistry - Oncology.
Between 1996 and 1997, as the director of New Lead Generation, he has set up the combinatorial chemistry group at RPR France.
He has directly contributed to the discovery and development of 3 molecules that are either on the market or in late phase II clinical trials.
One of the pioneers of bioinformatics in France, Jean established the bioinformatics laboratory at the Curie Institute Paris (1983-85) and was the director of the GSDIARL research consortium (1985-89) involving Sanofi, the CNRS Pharmacology Institute, the CNRS centre for macromolecular biochemistry and the Montpellier University Medical Centre.
From 1993 to 1996, he was appointed the Ministry of Research correspondent on Artificial Intelligence and Cognitive sciences.
He currently heads the "Rationality and machine learning" team that develops and studies the applications of machine learning techniques in a scientific discovery environment.
The methods and algorithms developed in his group have led to a number of patents and collaborations with large companies such as Areva, BNP Paribas and Fidal KPMG.
